Smc6 | structural maintenance of chromosomes 6

GeneMGI:1914491Synonyms: 3830418C19Rik, 2810489L22Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased lean body mass	1 supporting dataset	Smc6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.67x10^-5
increased total body fat amount	2 supporting datasets	Smc6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.37x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Smc6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating serum albumin level	1 supporting dataset	Smc6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.65x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smc6.

Associated images

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Histopathology

There is no histopathology data found for Smc6.

IMPC related publications

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External links

No external links available for Smc6.

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*Smc6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Smc6^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Smc6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Smc6^{tm81445(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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