Cul4a | cullin 4A

GeneMGI:1914487Synonyms: 2810470J21Rik

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Vision/eye Hematopoietic system Behavior/neurological

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Phy. System:



small testis	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.59x10^-9
abnormal testis morphology	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating potassium level	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.01x10^-5
decreased circulating chloride level	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.59x10^-7
enhanced cued conditioning behavior	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.29x10^-8
male infertility	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.91x10^-5
decreased mean platelet volume	1 supporting dataset	Cul4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.54x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cul4a.

Associated images

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Histopathology

There is no histopathology data found for Cul4a.

IMPC related publications

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External links

No external links available for Cul4a.

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*Cul4a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cul4a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cul4a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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