Lsm1 | LSM1 homolog, mRNA degradation associated

GeneMGI:1914457Synonyms: U6 small nuclear RNA associated, 2810025O06Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased locomotor activity	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.35x10^-5
increased grip strength	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.05x10^-5
hyperactivity	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.17x10^-5
dilated aorta	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.29x10^-10
abnormal lens morphology	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.21x10^-5
abnormal lens morphology	3 supporting datasets	Lsm1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.89x10^-6
decreased grip strength	2 supporting datasets	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.59x10^-8
cataract	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.33x10^-6
dilated aorta	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.32x10^-5
increased heart rate variability	1 supporting dataset	Lsm1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.19x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lsm1.

Associated images

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Histopathology

There is no histopathology data found for Lsm1.

IMPC related publications

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External links

No external links available for Lsm1.

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*Lsm1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lsm1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lsm1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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