Mkrn2 | makorin, ring finger protein, 2

GeneMGI:1914277Synonyms: 2610002L04Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Integument Hearing/vestibular/ear Hematopoietic system

12 No significant impact

6 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

decreased mean corpuscular hemoglobin concentration1 supporting datasetMkrn2em1(IMPC)WtsihomozygoteEarly adult9.17x10-5 
increased circulating aspartate transaminase level1 supporting datasetMkrn2tm1b(KOMP)WtsihomozygoteEarly adult5.11x10-8 
decreased dendritic epidermal T cell number1 supporting datasetMkrn2tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
male infertility1 supporting datasetMkrn2em1(IMPC)WtsihomozygoteEarly adultN/A * 
abnormal auditory brainstem response1 supporting datasetMkrn2tm1b(KOMP)WtsihomozygoteEarly adult1.61x10-11 
male infertility1 supporting datasetMkrn2tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mkrn2em1(IMPC)WtsiDeletionmouse
Mkrn2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Mkrn2tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Mkrn2tm1e(KOMP)WtsiTargeted, non-conditional allelees cell

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