Cep19 | centrosomal protein 19

GeneMGI:1914244Synonyms: 1500031L02Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Integument Adipose tissue Growth/size/body region Nervous system Vision/eye Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:51Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased total retina thickness	2 supporting datasets	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.54x10^-16
decreased bone mineral content	2 supporting datasets	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.28x10^-11
increased total body fat amount	2 supporting datasets	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.61x10^-23
decreased prepulse inhibition	1 supporting dataset	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.68x10^-5
decreased bone mineral density	1 supporting dataset	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.2x10^-11
abnormal retina outer nuclear layer morphology	2 supporting datasets	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.25x10^-30
female infertility	1 supporting dataset	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.06x10^-14
decreased body length	1 supporting dataset	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.92x10^-6
abnormal bone structure	1 supporting dataset	Cep19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.47x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cep19.

Associated images

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Histopathology

There is no histopathology data found for Cep19.

IMPC related publications

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External links

No external links available for Cep19.

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*Cep19^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cep19^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cep19^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cep19^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cep19^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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