Edem3 | ER degradation enhancer, mannosidase alpha-like 3

GeneMGI:1914217Synonyms: 2310050N11Rik

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Pigmentation Integument Behavior/neurological Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

128Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased bone mineral density	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.37x10^-5
abnormal coat/hair pigmentation	3 supporting datasets	Edem3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.66x10^-12
no spontaneous movement	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.66x10^-8
no spontaneous movement	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	heterozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	heterozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Edem3^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Edem3.

Associated images

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Histopathology

There is no histopathology data found for Edem3.

IMPC related publications

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External links

No external links available for Edem3.

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*Edem3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Edem3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Edem3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Edem3^{tm271889(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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