Bzw2 | basic leucine zipper and W2 domains 2

GeneMGI:1914162Synonyms: 1110001I24Rik, HSPC028

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

44Embryo tissues

Phenotypes

Phy. System:



decreased circulating iron level	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	3.47x10^-5
increased lean body mass	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.27x10^-6
decreased circulating glucose level	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	2.45x10^-8
abnormal lens morphology	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	2.15x10^-5
hyperactivity	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	9.16x10^-7
decreased exploration in new environment	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	3.53x10^-5
decreased circulating cholesterol level	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.57x10^-5
increased heart weight	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.73x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Bzw2^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.55x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bzw2.

Associated images

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Histopathology

There is no histopathology data found for Bzw2.

IMPC related publications

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External links

No external links available for Bzw2.

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*Bzw2^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Bzw2^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bzw2^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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