Nacc1 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing

GeneMGI:1914080Synonyms: 4930511N13Rik, 2010001H03Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Integument Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Vision/eye Behavior/neurological Skeleton Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased total retina thickness	2 supporting datasets	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.96x10^-11
decreased grip strength	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.38x10^-5
abnormal retina morphology	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.17x10^-19
polycystic kidney	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	5.07x10^-5
impaired glucose tolerance	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	7.82x10^-6
absent vibrissae	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.01x10^-15
hydrometra	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	5.66x10^-5
short tibia	1 supporting dataset	Nacc1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.3x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nacc1.

Associated images

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Histopathology

There is no histopathology data found for Nacc1.

IMPC related publications

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External links

No external links available for Nacc1.

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*Nacc1^{em1(IMPC)Hmgu}*	Intra-exon deletion	‌	mouse
*Nacc1^{tm250148(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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