Duoxa2 | dual oxidase maturation factor 2

GeneMGI:1914061Synonyms: 9030623N16Rik, Nip2

Physiological systems

18 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Cardiovascular system

5 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:77Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	1 supporting dataset	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.32x10^-5
increased CD8-positive, naive alpha-beta T cell number	2 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased KLRG1-positive NK cell number	6 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased mature B cell number	2 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased T cell number	5 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal snout morphology	2 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.11x10^-12
increased circulating fructosamine level	1 supporting dataset	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.66x10^-22
increased circulating iron level	1 supporting dataset	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.54x10^-18
decreased grip strength	4 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.68x10^-8
decreased B cell number	5 supporting datasets	Duoxa2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Duoxa2.

Associated images

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Histopathology

There is no histopathology data found for Duoxa2.

IMPC related publications

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External links

No external links available for Duoxa2.

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*Duoxa2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Duoxa2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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