Rbm22 | RNA binding motif protein 22

GeneMGI:1914060Synonyms: 8430430L24Rik

Physiological systems

22 / 24 physiological systems tested

15 Significantly impacted by the knock-out

 Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Embryo Nervous system Vision/eye Liver/biliary system Behavior/neurological Skeleton Mortality/aging

7 No significant impact

2 Not tested

Gene metrics:30Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

enlarged lymph nodes1 supporting datasetRbm22em1(IMPC)MbpheterozygoteLate adultN/A * 
preweaning lethality, complete penetrance1 supporting datasetRbm22tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal epididymis morphology1 supporting datasetRbm22em1(IMPC)MbpheterozygoteEarly adultN/A * 
abnormal heart morphology1 supporting datasetRbm22em1(IMPC)MbpheterozygoteLate adultN/A * 
enlarged heart1 supporting datasetRbm22em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal eye morphology1 supporting datasetRbm22em1(IMPC)MbpheterozygoteLate adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetRbm22tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
abnormal ovary morphology1 supporting datasetRbm22em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal liver morphology2 supporting datasetsRbm22em1(IMPC)MbpheterozygoteLate adultN/A * 
increased bone mineral content1 supporting datasetRbm22em1(IMPC)MbpheterozygoteEarly adult8.91x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rbm22em1(IMPC)MbpExon Deletionmouse
Rbm22tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Rbm22tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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