Gapvd1 | GTPase activating protein and VPS9 domains 1

GeneMGI:1913941Synonyms: 2010005B09Rik, 4432404J10Rik

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Immune system Integument Embryo Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged heart	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged kidney	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
anophthalmia	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small heart	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Gapvd1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged lymph nodes	2 supporting datasets	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
enlarged spleen	1 supporting dataset	Gapvd1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gapvd1.

Associated images

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Histopathology

There is no histopathology data found for Gapvd1.

IMPC related publications

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External links

No external links available for Gapvd1.

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*Gapvd1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Gapvd1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gapvd1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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