Tpgs2 | tubulin polyglutamylase complex subunit 2

GeneMGI:1913898Synonyms: 5730437P09Rik, 5730494M16Rik

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased circulating creatinine level	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Late adult	3.81x10^-5
decreased thigmotaxis	2 supporting datasets	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.43x10^-6
abnormal sleep behavior	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.55x10^-6
decreased circulating free fatty acids level	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.77x10^-6
increased thigmotaxis	2 supporting datasets	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Late adult	7.07x10^-7
decreased exploration in new environment	2 supporting datasets	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.3x10^-5
male infertility	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased locomotor activity	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5x10^-5
increased erythrocyte cell number	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Late adult	2.53x10^-6
abnormal bone structure	1 supporting dataset	Tpgs2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.08x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tpgs2.

Associated images

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Histopathology

There is no histopathology data found for Tpgs2.

IMPC related publications

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External links

No external links available for Tpgs2.

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*Tpgs2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Tpgs2^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Tpgs2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tpgs2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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