Dph6 | diphthamine biosynthesis 6

GeneMGI:1913882Synonyms: 5730421E18Rik, Atpbd4, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Hematopoietic system Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:35Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased effector memory CD8-positive, alpha-beta T cell number	2 supporting datasets	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	4 supporting datasets	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	2 supporting datasets	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.53x10^-5
increased circulating creatinine level	1 supporting dataset	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.94x10^-10
vertebral transformation	1 supporting dataset	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.79x10^-6
increased CD5-positive gamma-delta T cell number	4 supporting datasets	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased hematocrit	1 supporting dataset	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.31x10^-7
decreased mature B cell number	2 supporting datasets	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive T-helper cell number	1 supporting dataset	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased memory-marker gamma-delta T cell number	1 supporting dataset	Dph6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dph6.

Associated images

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Histopathology

There is no histopathology data found for Dph6.

IMPC related publications

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External links

No external links available for Dph6.

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*Dph6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dph6^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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