Farsa | phenylalanyl-tRNA synthetase, alpha subunit

GeneMGI:1913840Synonyms: Farsla, 0610012A19Rik

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Skeleton Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating insulin level1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult5.06x10-7 
decreased bone mineral content1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult3.52x10-6 
decreased circulating sodium level1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult2.3x10-7 
preweaning lethality, complete penetrance1 supporting datasetFarsatm2a(EUCOMM)WtsihomozygoteEarly adultN/A * 
impaired glucose tolerance1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult2.97x10-6 
decreased leukocyte cell number1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult9.08x10-5 
decreased circulating chloride level1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult1.66x10-7 
decreased bone mineral density1 supporting datasetFarsatm2a(EUCOMM)WtsiheterozygoteEarly adult2.77x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Farsatm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Farsatm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse

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