Rwdd1 | RWD domain containing 1

GeneMGI:1913771Synonyms: 2700069A07Rik, 2610002D06Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Vision/eye Hematopoietic system Skeleton

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.8x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.33x10^-6
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased Ly6C-positive mature NK cell number	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.49x10^-5
increased memory-marker gamma-delta T cell number	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.13x10^-6
decreased regulatory T cell number	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.16x10^-5
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Rwdd1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rwdd1.

Associated images

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Histopathology

There is no histopathology data found for Rwdd1.

IMPC related publications

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External links

No external links available for Rwdd1.

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*Rwdd1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Rwdd1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rwdd1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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