Prrc2c | proline-rich coiled-coil 2C

GeneMGI:1913754Synonyms: Bat2d, 1810043M20Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Integument Embryo Growth/size/body region Hearing/vestibular/ear Nervous system Behavior/neurological Mortality/aging

12 No significant impact

5 Not tested

Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal neural tube morphology1 supporting datasetPrrc2cem1(IMPC)JhomozygoteE9.5N/A * 
abnormal neural tube closure1 supporting datasetPrrc2cem1(IMPC)JhomozygoteE9.5N/A * 
abnormal embryo size1 supporting datasetPrrc2cem1(IMPC)JhomozygoteE18.5N/A * 
abnormal vocalization1 supporting datasetPrrc2cem1(IMPC)JheterozygoteEarly adult2.42x10-10 
hyperactivity2 supporting datasetsPrrc2cem1(IMPC)JheterozygoteEarly adult2.24x10-6 
preweaning lethality, complete penetrance1 supporting datasetPrrc2cem1(IMPC)JhomozygoteEarly adultN/A * 
abnormal coat/ hair morphology1 supporting datasetPrrc2cem1(IMPC)JheterozygoteEarly adult2.71x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Prrc2cem1(IMPC)JExon Deletionmouse
Prrc2ctm460365(L1L2_GT1_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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