Fis1 | fission, mitochondrial 1

GeneMGI:1913687Synonyms: Ttc11, 2010003O14Rik

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Mortality/aging

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating bilirubin level1 supporting datasetFis1tm1b(EUCOMM)HmguheterozygoteEarly adult6.35x10-6 
preweaning lethality, complete penetrance1 supporting datasetFis1tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fis1tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Fis1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Fis1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Fis1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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