Asf1a | anti-silencing function 1A histone chaperone

GeneMGI:1913653Synonyms: 2310079C17Rik

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal embryo turning	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.35x10^-8
abnormal neural tube closure	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Asf1a^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asf1a.

Associated images

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Histopathology

There is no histopathology data found for Asf1a.

IMPC related publications

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External links

No external links available for Asf1a.

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*Asf1a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Asf1a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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