Exosc3 | exosome component 3

GeneMGI:1913612Synonyms: 2310005D06Rik

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Mortality/aging Renal/urinary system

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

34Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	2 supporting datasets	Exosc3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Exosc3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Exosc3^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Exosc3^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.45x10^-5
abnormal kidney morphology	1 supporting dataset	Exosc3^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Exosc3^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Exosc3^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Exosc3.

Associated images

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Histopathology

There is no histopathology data found for Exosc3.

IMPC related publications

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External links

No external links available for Exosc3.

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*Exosc3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Exosc3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Exosc3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Exosc3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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