Mplkip | M-phase specific PLK1 intereacting protein

GeneMGI:1913558Synonyms: 2810021B07Rik, C330007M08Rik

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Integument Growth/size/body region Behavior/neurological Skeleton Cardiovascular system Craniofacial Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal testis morphology	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.55x10^-5
abnormal kidney morphology	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.38x10^-5
decreased thigmotaxis	2 supporting datasets	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.37x10^-6
abnormal behavior	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.38x10^-6
increased heart weight	2 supporting datasets	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.79x10^-6
abnormal pancreas morphology	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal snout morphology	1 supporting dataset	Mplkip^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.73x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mplkip.

Associated images

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Histopathology

There is no histopathology data found for Mplkip.

IMPC related publications

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External links

No external links available for Mplkip.

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*Mplkip^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Mplkip^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mplkip^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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