Smim8 | small integral membrane protein 8

GeneMGI:1913541Synonyms: 1810030N24Rik, 2810406B13Rik

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Skeleton Mortality/aging

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Smim8^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.22x10^-6
decreased prepulse inhibition	2 supporting datasets	Smim8^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.1x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Smim8^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Smim8^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.91x10^-5
increased circulating phosphate level	1 supporting dataset	Smim8^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.12x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smim8.

Associated images

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Histopathology

There is no histopathology data found for Smim8.

IMPC related publications

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External links

No external links available for Smim8.

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*Smim8^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Smim8^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Smim8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Smim8^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Smim8^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Smim8^{tm47134(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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