Dnase2b | deoxyribonuclease II beta

GeneMGI:1913283Synonyms: Dlad, DnaseIIb

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



tremors	1 supporting dataset	Dnase2b^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	6.63x10^-5
increased thermal nociceptive threshold	1 supporting dataset	Dnase2b^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.87x10^-5
abnormal behavior	1 supporting dataset	Dnase2b^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.66x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Dnase2b^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.86x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Dnase2b^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.84x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnase2b.

Associated images

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Histopathology

There is no histopathology data found for Dnase2b.

IMPC related publications

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External links

No external links available for Dnase2b.

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*Dnase2b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dnase2b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dnase2b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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