Crbn | cereblon

GeneMGI:1913277Synonyms: 2610203G15Rik, 2900045O07Rik

Physiological systems

22 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Digestive/alimentary Nervous system Vision/eye

19 No significant impact

2 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition3 supporting datasetsCrbntm1b(KOMP)WtsihomozygoteEarly adult1.11x10-7 
abnormal cecum morphology1 supporting datasetCrbntm1b(KOMP)WtsihomozygoteEarly adultN/A * 
absent optic nerve1 supporting datasetCrbntm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal eye morphology1 supporting datasetCrbntm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Crbntm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Crbntm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Crbntm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Crbntm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Crbntm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
mouse

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