Pde4dip | phosphodiesterase 4D interacting protein (myomegalin)
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Vision/eye Hematopoietic system Skeleton Mortality/aging
17 No significant impact
3 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| increased bone mineral content | 1 supporting dataset | Pde4diptm1b(KOMP)Wtsi | heterozygote | Early adult | 5.86x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Pde4diptm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Pde4diptm1b(KOMP)Wtsi | heterozygote | Early adult | 2.45x10-5 | ||
| abnormal eye anterior chamber depth | 1 supporting dataset | Pde4diptm1b(KOMP)Wtsi | heterozygote | Early adult | 1.38x10-6 | ||
| decreased total retina thickness | 1 supporting dataset | Pde4diptm1b(KOMP)Wtsi | heterozygote | Early adult | 4.39x10-5 | ||
| increased hemoglobin content | 1 supporting dataset | Pde4diptm1b(KOMP)Wtsi | heterozygote | Early adult | 4.37x10-7 | ||
| increased cornea thickness | 1 supporting dataset | Pde4diptm1b(KOMP)Wtsi | heterozygote | Early adult | 3.28x10-5 |
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External links
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| Pde4diptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pde4diptm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pde4diptm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |