Actn4 | actinin alpha 4

GeneMGI:1890773

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Growth/size/body region Vision/eye Cardiovascular system Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased heart weight	1 supporting dataset	Actn4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5x10^-12
preweaning lethality, incomplete penetrance	1 supporting dataset	Actn4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Actn4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.73x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Actn4.

Associated images

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Histopathology

There is no histopathology data found for Actn4.

IMPC related publications

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External links

No external links available for Actn4.

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*Actn4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Actn4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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