Nherf2 | NHERF family PDZ scaffold protein 2

GeneMGI:1890662Synonyms: Sryip1, Sip1, +9 more

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Nherf2^{tm2a(EUCOMM)Hmgu}	homozygote	Early adult	3.06x10^-33
increased circulating alkaline phosphatase level	1 supporting dataset	Nherf2^{tm2a(EUCOMM)Hmgu}	homozygote	Early adult	2.9x10^-5
decreased hematocrit	1 supporting dataset	Nherf2^{tm2a(EUCOMM)Hmgu}	homozygote	Early adult	1.05x10^-15
decreased erythrocyte cell number	1 supporting dataset	Nherf2^{tm2a(EUCOMM)Hmgu}	homozygote	Early adult	2.66x10^-19
decreased hemoglobin content	1 supporting dataset	Nherf2^{tm2a(EUCOMM)Hmgu}	homozygote	Early adult	1.49x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nherf2.

Associated images

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Histopathology

There is no histopathology data found for Nherf2.

IMPC related publications

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External links

No external links available for Nherf2.

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*Nherf2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nherf2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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