Dusp12 | dual specificity phosphatase 12

GeneMGI:1890614Synonyms: VH1, LMW-DSP4, +4 more

Physiological systems

22 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Endocrine/exocrine gland Nervous system Mortality/aging

19 No significant impact

2 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsDusp12em1(IMPC)MbphomozygoteEarly adultN/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetDusp12em1(IMPC)MbphomozygoteE15.5N/A * 
embryonic lethality prior to organogenesis1 supporting datasetDusp12em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal adrenal gland morphology1 supporting datasetDusp12em1(IMPC)MbpheterozygoteEarly adultN/A * 
increased prepulse inhibition1 supporting datasetDusp12em1(IMPC)MbpheterozygoteEarly adult9.25x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dusp12em1(IMPC)MbpInter-exon deletionmouse
Dusp12tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Dusp12tm357070(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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