Pes1 | pescadillo ribosomal biogenesis factor 1

GeneMGI:1890613

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Mortality/aging Craniofacial

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased circulating fructosamine level	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.26x10^-5
increased mean platelet volume	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.72x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
abnormal snout morphology	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.06x10^-5
decreased circulating total protein level	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.53x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating serum albumin level	1 supporting dataset	Pes1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.52x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pes1.

Associated images

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Histopathology

There is no histopathology data found for Pes1.

IMPC related publications

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External links

No external links available for Pes1.

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*Pes1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pes1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pes1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pes1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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