Atp6v0b | ATPase, H+ transporting, lysosomal V0 subunit B

GeneMGI:1890510Synonyms: Atp6f, 2310024H13Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased total body fat amount	2 supporting datasets	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	1.34x10^-9
increased hematocrit	1 supporting dataset	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	1.63x10^-5
decreased lean body mass	2 supporting datasets	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	1.18x10^-5
decreased exploration in new environment	1 supporting dataset	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	3.78x10^-5
hyperactivity	1 supporting dataset	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	2.11x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Atp6v0b^em1(IMPC)J	homozygote	Early adult	N/A ^*
abnormal behavior	1 supporting dataset	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	8.75x10^-5
decreased bone mineral content	2 supporting datasets	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	1.31x10^-11
decreased bone mineral density	1 supporting dataset	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	1.87x10^-5
decreased locomotor activity	1 supporting dataset	Atp6v0b^em1(IMPC)J	heterozygote	Early adult	4.79x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp6v0b.

Associated images

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Histopathology

There is no histopathology data found for Atp6v0b.

IMPC related publications

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External links

No external links available for Atp6v0b.

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*Atp6v0b^em1(IMPC)J*	Whole-gene deletion	‌	mouse
*Atp6v0b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Atp6v0b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Atp6v0b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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