Foxo1 | forkhead box O1

GeneMGI:1890077Synonyms: Fkhr1, FKHR, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased mean corpuscular volume	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.2x10^-5
increased aggression	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.39x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.64x10^-5
increased circulating bilirubin level	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.71x10^-5
decreased erythrocyte cell number	1 supporting dataset	Foxo1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.43x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Foxo1.

Associated images

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Histopathology

There is no histopathology data found for Foxo1.

IMPC related publications

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External links

No external links available for Foxo1.

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*Foxo1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Foxo1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Foxo1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Foxo1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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