Nub1 | negative regulator of ubiquitin-like proteins 1

GeneMGI:1889001Synonyms: 6330412F12Rik, BS4, +2 more

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

36Embryo tissues

Phenotypes

Phy. System:



abnormal heart morphology	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased effector memory CD8-positive, alpha-beta T cell number	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.38x10^-5
decreased CD4-negative NK T cell number	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.16x10^-6
decreased NK T cell number	2 supporting datasets	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.33x10^-10
abnormal optic disk morphology	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.33x10^-6
abnormal lens morphology	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4x10^-5
enlarged spleen	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased circulating iron level	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.15x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.43x10^-7
increased Ly6C-positive NK T cell number	1 supporting dataset	Nub1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.09x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nub1.

Associated images

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Histopathology

There is no histopathology data found for Nub1.

IMPC related publications

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External links

No external links available for Nub1.

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*Nub1^{tm181653(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Nub1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nub1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nub1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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