Rexo2 | RNA exonuclease 2

GeneMGI:1888981Synonyms: Sfn, 1810038D15Rik, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased neutrophil cell number	2 supporting datasets	Rexo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.15x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Rexo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.89x10^-11
preweaning lethality, complete penetrance	1 supporting dataset	Rexo2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased lymphocyte cell number	1 supporting dataset	Rexo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.41x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Rexo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.76x10^-11
increased circulating serum albumin level	1 supporting dataset	Rexo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.04x10^-5
increased circulating cholesterol level	1 supporting dataset	Rexo2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.61x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rexo2.

Associated images

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Histopathology

There is no histopathology data found for Rexo2.

IMPC related publications

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External links

No external links available for Rexo2.

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*Rexo2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rexo2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rexo2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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