Slc12a5 | solute carrier family 12, member 5

GeneMGI:1862037Synonyms: KCC2

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Embryo Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Skeleton Mortality/aging Cardiovascular system Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



microphthalmia	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
decreased bone mineral content	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	heterozygote	Early adult	9.17x10^-5
edema	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Slc12a5^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal skin morphology	2 supporting datasets	Slc12a5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal stomach morphology	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal duodenum morphology	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal colon morphology	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Slc12a5^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc12a5.

Associated images

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Histopathology

There is no histopathology data found for Slc12a5.

IMPC related publications

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External links

No external links available for Slc12a5.

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*Slc12a5^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Slc12a5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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