Pigo | phosphatidylinositol glycan anchor biosynthesis, class O

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Mortality/aging Cardiovascular system

18 No significant impact

4 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues

Phenotypes

embryonic lethality prior to organogenesis1 supporting datasetPigotm1b(EUCOMM)WtsihomozygoteE9.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsPigotm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased heart rate variability1 supporting datasetPigotm1b(EUCOMM)WtsiheterozygoteEarly adult6.22x10-5 
cardiovascular system phenotype1 supporting datasetPigotm1b(EUCOMM)WtsiheterozygoteEarly adult4.88x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pigotm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Pigotm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Pigotm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pigotm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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