Ubr2 | ubiquitin protein ligase E3 component n-recognin 2

GeneMGI:1861099Synonyms: ENSMUSG00000043296, 9930021A08Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Embryo Nervous system Liver/biliary system Cardiovascular system Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

83Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hemorrhage	1 supporting dataset	Ubr2^{tm1e.1(KOMP)Mbp}	homozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Ubr2^{tm1e.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
spina bifida	1 supporting dataset	Ubr2^{tm1e.1(KOMP)Mbp}	heterozygote	E15.5	N/A ^*
spina bifida	1 supporting dataset	Ubr2^{tm1e.1(KOMP)Mbp}	homozygote	E15.5	N/A ^*
abnormal liver morphology	1 supporting dataset	Ubr2^{tm1e.1(KOMP)Mbp}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Ubr2^{tm1e.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
hemorrhage	1 supporting dataset	Ubr2^{tm1e.1(KOMP)Mbp}	heterozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ubr2.

Associated images

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Histopathology

There is no histopathology data found for Ubr2.

IMPC related publications

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External links

No external links available for Ubr2.

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*Ubr2^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ubr2^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Ubr2^{tm1e.1(KOMP)Mbp}*	Promoter excision from Targeted, non-conditional allele	‌	mouse

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