Actr8 | ARP8 actin-related protein 8

GeneMGI:1860775Synonyms: ARP8, 5730542K05Rik

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:52Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased hematocrit	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.22x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
hyperactivity	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.85x10^-5
decreased erythrocyte cell number	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.89x10^-5
increased circulating sodium level	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.49x10^-5
decreased hemoglobin content	1 supporting dataset	Actr8^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.6x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Actr8.

Associated images

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Histopathology

There is no histopathology data found for Actr8.

IMPC related publications

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External links

No external links available for Actr8.

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*Actr8^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Actr8^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Actr8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Actr8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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