Rnf5 | ring finger protein 5

GeneMGI:1860076Synonyms: 2410131O05Rik

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Integument Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged thymus	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
enlarged gallbladder	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal gallbladder morphology	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
increased freezing behavior	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.72x10^-6
abnormal spleen morphology	1 supporting dataset	Rnf5^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rnf5.

Associated images

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Histopathology

There is no histopathology data found for Rnf5.

IMPC related publications

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External links

No external links available for Rnf5.

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*Rnf5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Rnf5^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Rnf5^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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