Atp8b1 | ATPase, class I, type 8B, member 1

GeneMGI:1859665Synonyms: FIC1, Ic

Physiological systems

20 / 24 physiological systems tested

16 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Behavior/neurological Skeleton

4 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:48Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased bone mineral content	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Late adult	2.38x10^-16
abnormal startle reflex	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Late adult	5.02x10^-10
small seminal vesicle	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased circulating triglyceride level	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Late adult	9x10^-22
abnormal auditory brainstem response	6 supporting datasets	Atp8b1^em1(IMPC)Tcp	homozygote	Early adult	2.77x10^-9
abnormal bone structure	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Early adult	3.6x10^-7
decreased bone mineral density	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Early adult	1.16x10^-17
small seminal vesicle	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal startle reflex	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Middle aged adult	4.9x10^-8
decreased hemoglobin content	1 supporting dataset	Atp8b1^em1(IMPC)Tcp	homozygote	Early adult	1.57x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp8b1.

Associated images

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Histopathology

There is no histopathology data found for Atp8b1.

IMPC related publications

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External links

No external links available for Atp8b1.

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*Atp8b1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Atp8b1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Atp8b1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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