Ftsj1 | FtsJ RNA 2'-O-methyltransferase 1

GeneMGI:1859648Synonyms: Sfc12

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:98Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased total retina thickness	2 supporting datasets	Ftsj1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.07x10^-10
abnormal retina inner nuclear layer morphology	2 supporting datasets	Ftsj1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
decreased circulating aspartate transaminase level	1 supporting dataset	Ftsj1^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	1.75x10^-8
decreased circulating alanine transaminase level	1 supporting dataset	Ftsj1^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	3.85x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Ftsj1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.22x10^-5
hyperactivity	5 supporting datasets	Ftsj1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.24x10^-15
abnormal retina inner nuclear layer morphology	2 supporting datasets	Ftsj1^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	6.62x10^-80
decreased total retina thickness	2 supporting datasets	Ftsj1^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	6.8x10^-8
decreased circulating phosphate level	1 supporting dataset	Ftsj1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.39x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ftsj1.

Associated images

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Histopathology

There is no histopathology data found for Ftsj1.

IMPC related publications

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External links

No external links available for Ftsj1.

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*Ftsj1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ftsj1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ftsj1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ftsj1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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