Pdgfc | platelet-derived growth factor, C polypeptide

GeneMGI:1859631Synonyms: PDGF-C, 1110064L01Rik

Physiological systems

23 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

13 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased monocyte cell number	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	4.24x10^-5
enlarged spleen	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased CD4-negative, CD25-positive NK T cell number	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	8.76x10^-5
increased red blood cell distribution width	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	5.6x10^-7
abnormal kidney morphology	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
decreased heart rate	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	1.22x10^-5
abnormal lean body mass	1 supporting dataset	Pdgfc^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	5x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdgfc.

Associated images

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Histopathology

There is no histopathology data found for Pdgfc.

IMPC related publications

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External links

No external links available for Pdgfc.

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*Pdgfc^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Pdgfc^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pdgfc^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pdgfc^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Pdgfc^{tm46906(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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