Rnf10 | ring finger protein 10

Physiological systems

24 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Immune system Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

10 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:67Significant phenotypes

0Associated diseases

Expression examined in:158Adult tissues

73Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



abnormal spleen morphology	1 supporting dataset	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	4 supporting datasets	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.7x10^-8
decreased total retina thickness	2 supporting datasets	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.88x10^-10
decreased thigmotaxis	2 supporting datasets	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.82x10^-5
abnormal behavior	2 supporting datasets	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.87x10^-14
shortened ST segment	1 supporting dataset	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.41x10^-5
increased leukocyte cell number	1 supporting dataset	Rnf10^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.49x10^-5
abnormal gait	1 supporting dataset	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.79x10^-6
decreased exploration in new environment	1 supporting dataset	Rnf10^em1(IMPC)J	homozygote	Late adult	4.26x10^-5
decreased circulating cholesterol level	1 supporting dataset	Rnf10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.59x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rnf10.

Associated images

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Histopathology

There is no histopathology data found for Rnf10.

IMPC related publications

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External links

No external links available for Rnf10.

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*Rnf10^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Rnf10^em1(IMPC)J*	Exon Deletion	‌	mouse
*Rnf10^em1(IMPC)Mbp*	Indel	‌	mouse
*Rnf10^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Rnf10^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rnf10^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Rnf10^{tm303169(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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