Cnot4 | CCR4-NOT transcription complex, subunit 4

GeneMGI:1859026Synonyms: Not4h, Not4, +1 more

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Skeleton Mortality/aging

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating alkaline phosphatase level	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.89x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.59x10^-9
decreased KLRG1-positive NK cell number	2 supporting datasets	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
decreased lean body mass	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.45x10^-7
abnormal bone structure	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.11x10^-7
decreased body length	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.46x10^-6
abnormal epidermal immune compartment	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Cnot4^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.26x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cnot4.

Associated images

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Histopathology

There is no histopathology data found for Cnot4.

IMPC related publications

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External links

No external links available for Cnot4.

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*Cnot4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cnot4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cnot4^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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