Cdkl2 | cyclin dependent kinase like 2

GeneMGI:1858227Synonyms: 5330436L21Rik, KKIAMRE, +1 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Skeleton

13 No significant impact

7 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues

Phenotypes

decreased circulating phosphate level1 supporting datasetCdkl2tm1b(EUCOMM)HmguhomozygoteEarly adult3.12x10-6 
abnormal spleen morphology2 supporting datasetsCdkl2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased circulating aspartate transaminase level1 supporting datasetCdkl2tm1b(EUCOMM)HmguhomozygoteEarly adult2.06x10-6 
decreased bone mineral content1 supporting datasetCdkl2tm1b(EUCOMM)HmguhomozygoteEarly adult4.87x10-5 
decreased circulating potassium level1 supporting datasetCdkl2tm1b(EUCOMM)HmguhomozygoteEarly adult3.5x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cdkl2tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Cdkl2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cdkl2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Cdkl2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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