Clpp | caseinolytic mitochondrial matrix peptidase proteolytic subunit

GeneMGI:1858213Synonyms: D17Wsu160e

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:39Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.15x10^-18
increased monocyte cell number	3 supporting datasets	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.75x10^-14
increased hemoglobin content	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.06x10^-6
increased mature B cell number	2 supporting datasets	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive NK cell number	7 supporting datasets	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased CD4-positive NK T cell number	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased red blood cell distribution width	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.74x10^-6
decreased lean body mass	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.3x10^-7
thrombocytopenia	1 supporting dataset	Clpp^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.18x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Clpp.

Associated images

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Histopathology

There is no histopathology data found for Clpp.

IMPC related publications

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External links

No external links available for Clpp.

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*Clpp^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Clpp^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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