Tmod2 | tropomodulin 2

GeneMGI:1355335Synonyms: neural tropomodulin, N-Tmod, +1 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Hematopoietic system Behavior/neurological Skeleton

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased thigmotaxis	6 supporting datasets	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.38x10^-14
hyperactivity	9 supporting datasets	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.9x10^-53
decreased erythrocyte cell number	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.18x10^-5
abnormal behavior	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.38x10^-14
decreased bone mineral content	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.29x10^-6
increased anxiety-related response	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.81x10^-5
abnormal bone structure	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.53x10^-6
decreased bone mineral density	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.12x10^-7
increased exploration in new environment	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.18x10^-5
decreased hemoglobin content	1 supporting dataset	Tmod2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.02x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmod2.

Associated images

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Histopathology

There is no histopathology data found for Tmod2.

IMPC related publications

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External links

No external links available for Tmod2.

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*Tmod2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tmod2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tmod2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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