Stag3 | STAG3 cohesin complex component

GeneMGI:1355311Synonyms: SA-2, stromalin 3

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Behavior/neurological Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

3Associated diseases

Expression examined in:49Adult tissues

50Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal bone structure	1 supporting dataset	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	1.68x10^-12
decreased bone mineral density	1 supporting dataset	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	7.27x10^-13
small testis	1 supporting dataset	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
male infertility	1 supporting dataset	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	2 supporting datasets	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Late adult	2.48x10^-5
increased total body fat amount	2 supporting datasets	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	5.49x10^-9
decreased grip strength	1 supporting dataset	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	8.91x10^-6
decreased bone mineral content	2 supporting datasets	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	3.05x10^-16
decreased lean body mass	2 supporting datasets	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	1.7x10^-5
female infertility	1 supporting dataset	Stag3^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Stag3.

Associated images

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Histopathology

There is no histopathology data found for Stag3.

IMPC related publications

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External links

No external links available for Stag3.

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*Stag3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Stag3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Stag3^{tm1e.1(KOMP)Wtsi}*	Promoter excision from Targeted, non-conditional allele	‌	mouse

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