Tfr2 | transferrin receptor 2

GeneMGI:1354956Synonyms: Tfr2, Trfr2

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased mean corpuscular volume	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	3.41x10^-23
decreased red blood cell distribution width	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	2.94x10^-5
decreased erythrocyte cell number	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	1.07x10^-10
decreased erythrocyte cell number	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Early adult	1.28x10^-6
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Early adult	5.77x10^-6
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	9.56x10^-6
abnormal liver morphology	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Early adult	1.37x10^-23
abnormal rectum morphology	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Tfr2^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tfr2.

Associated images

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Histopathology

There is no histopathology data found for Tfr2.

IMPC related publications

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External links

No external links available for Tfr2.

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*Tfr2^{em1(IMPC)Rbrc}*	Indel	‌	mouse
*Tfr2^{tm197178(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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