Atp11a | ATPase, class VI, type 11A

GeneMGI:1354735Synonyms: LOC100045280, 4930558F19Rik, +2 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Skeleton Mortality/aging

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Atp11a^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Atp11a^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	9.25x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Atp11a^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	1.81x10^-5
increased leukocyte cell number	1 supporting dataset	Atp11a^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	2.22x10^-7
decreased circulating cholesterol level	1 supporting dataset	Atp11a^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	1.21x10^-5
increased bone mineral density	1 supporting dataset	Atp11a^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	3.08x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp11a.

Associated images

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Histopathology

There is no histopathology data found for Atp11a.

IMPC related publications

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External links

No external links available for Atp11a.

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*Atp11a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Atp11a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	mouse

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