Fbxl3 | F-box and leucine-rich repeat protein 3

GeneMGI:1354702Synonyms: Fbl3a, Play68, +2 more

Physiological systems

23 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Muscle Nervous system Vision/eye Digestive/alimentary Liver/biliary system Hematopoietic system Cardiovascular system

10 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased lean body mass	1 supporting dataset	Fbxl3^{Gt(CB0226)Wtsi}	homozygote	Early adult	8.7x10^-5
abnormal retina morphology	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.07x10^-7
abnormal heart morphology	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Fbxl3^{Gt(CB0226)Wtsi}	homozygote	Early adult	4.98x10^-5
decreased lean body mass	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.84x10^-5
enlarged testis	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.84x10^-6
abnormal testis morphology	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal brain morphology	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Fbxl3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxl3.

Associated images

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Histopathology

There is no histopathology data found for Fbxl3.

IMPC related publications

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External links

No external links available for Fbxl3.

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*Fbxl3^{Gt(CB0226)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Fbxl3^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Fbxl3^{tm380507(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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