Tmprss2 | transmembrane protease, serine 2

GeneMGI:1354381Synonyms: D16Ertd61e, epitheliasin

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Muscle Hearing/vestibular/ear Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



improved glucose tolerance	1 supporting dataset	Tmprss2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	1.14x10^-5
abnormal thymus morphology	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal epididymis morphology	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged epididymis	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased cardiac muscle contractility	1 supporting dataset	Tmprss2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	6.08x10^-5
abnormal testis morphology	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Tmprss2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	1.64x10^-5
abnormal auditory brainstem response	1 supporting dataset	Tmprss2^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.62x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmprss2.

Associated images

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Histopathology

There is no histopathology data found for Tmprss2.

IMPC related publications

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External links

No external links available for Tmprss2.

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*Tmprss2^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Tmprss2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tmprss2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tmprss2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tmprss2^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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